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Web24 aug. 2024 · Methocarbamol is available in 500- and 750-milligram (mg) tablets. For adults with muscle stiffness, the typical dosage is 1,500 mg, four times daily. Web10 feb. 2024 · Generic: 500 mg, 750 mg Pharmacology Mechanism of Action Causes skeletal muscle relaxation by general CNS depression Pharmacokinetics/Pharmacodynamics Metabolism Hepatic via dealkylation and hydroxylation Excretion Urine (primarily as metabolites); Clearance: Adults: 0.2 to 0.8 … WebMethocarbamol is produced in 500- and 750-mg tablets and has a recommended dosage range of 4000 to 4500 mg daily in 3 or 4 divided doses. For severe conditions, dosage as high as 6 to 8 g may be given for the first 48 to 72 hours. ... which has been found to increase acidosis and urea retention in renal-impaired humans ... christophe bahuet