2024 Gwas and obesity

Gwas and obesity

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August undefined, 2024

WebJan 25, 2014 · The 39 included studies were reviewed in depth to find SNPs associated with to BMI, waist circumference, waist-hip ratio, fat percentage, fat mass or metabolic … WebJan 29, 2024 · By the two sample MR approach using the MR-Base platform , this study aims to investigate the causal effects of obesity and T2D in COVID-19-associated hospitalization in European populations based on two large GWASs on obesity and T2D, including the GWAS on obesity harboring 263,407 individuals of European ancestry , …

Sequencing of 640,000 exomes identifies - Science

WebFeb 2, 2024 · Abstract. Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk factors for cardiovascular disease, and are destined to increase in importance given the global changes in … WebJan 21, 2024 · Obesity and the distribution of fat within the body are risk factors for cardiometabolic diseases. Here, Rask-Andersen et al. perform GWAS for bio-electrical impedance measurements in UK Biobank ... github repo settings

Identification of Genetic Variants for Female Obesity and …

WebThe discovery of FTO as the first obesity susceptibility gene. In 2007, within a time period of three months, two studies claimed the discovery of FTO as the first GWAS-identified obesity-susceptibility gene. 8-10 FTO was first discovered through a GWAS of type 2 diabetes in Europeans, comparing 1,924 cases and 2,938 controls. 8 A cluster of single … WebApr 28, 2011 · Results. We analyzed genotype data for 520 cases and 540 control subjects, and performed a GWAS on obesity as a binary trait. We observed a strong association of obesity to the FTO gene, with the most … WebSep 20, 2024 · Obesity is a complex multifactorial disorder with genetic and environmental factors. There is an increase in the worldwide prevalence of obesity in both developed … fur in painter 12

Genome-wide association analyses identify 143 risk variants and ...

Genome-wide association studies of obesity and metabolic …

WebAug 1, 2024 · Genome-Wide Association Studies (GWAS) have been ongoing since 2007 to help associate specific genetic variations with certain diseases. Around 250 genes are … WebAmong the general population, there is a category of individuals with an innate predisposition to obesity. In recent decades, the increase in the prevalence of obesity and related diseases worldwide indicates the need to study the etiological factors associated with its development. ... Most of the GWAS studies have been conducted in the ... furino corner rackWebJul 2, 2024 · Obesity is linked to many human diseases, including diabetes, cancer, and heart disease. There is thus great interest in understanding how genes predispose individuals to, or protect individuals from, obesity. ... furino and hamlin

"WebJul 22, 2024 · We also assessed the causal effect of several obesity-related factors including arm fat mass, arm fat-free mass, waist circumference, lipid profile, and glycemic traits on the risk of CTS with summary data from publicly available GWAS (Scott et al., 2012; Willer et al., 2013; Wheeler et al., 2024). " - Gwas and obesity

Gwas and obesity

Computational analyses of obesity associated loci generated by

WebJan 20, 2024 · Author summary Overweight and obese individuals are at risk for various medical conditions in Taiwan. Thus, we performed a genome-wide association study (GWAS) on four adiposity traits, … WebThe Effect of Obesity on the Pharmacokinetics of Pantoprazole in Children and Adolescents The Effect of Obesity on the Pharmacokinetics of ... (39 to less than 42 weeks gestation) were analyzed. GWAS, phenotype, and clinical data are available in dbGaP. Cases were 1:1 matched with controls according to race and ethnicity, maternal age, and ...

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WebApr 7, 2024 · One plausible, but largely unexplored source of heterogeneity in obesity-associated CVD risk is the impact of body fat distribution (central versus overall obesity), … WebThe Effect of Obesity on the Pharmacokinetics of Pantoprazole in Children and Adolescents The Effect of Obesity on the Pharmacokinetics of ... (39 to less than 42 weeks gestation) …

WebJan 24, 2024 · Obesity-associated disorders are amongst the leading causes of morbidity and mortality worldwide. Most genome-wide association studies (GWAS) have focused on body mass index (BMI = weight in Kg divided by height squared (m 2)) and obesity, but to date no genetic association study testing thin and healthy individuals has been … WebGenome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity traits have identified more than 300 single-nucleotide …

WebMethods: Two-stage GWAS was conducted to identify genetic variants influencing obesity traits (such as body mass index [BMI], waist–hip ratio [WHR], and waist circumference [WC]) in Korean women. Two-sample Mendelian randomization (MR) analysis was employed to evaluate the causal effect of variants as genetic instruments for female obesity on ... WebSep 7, 2024 · Author summary Human GWAS have identified hundreds of genetic variants associated with human obesity. The genes being regulated by these variants at the …

WebMay 1, 2024 · Both body mass index (BMI) obesity and MPDs have substantial heritability, ... We used GWAS summary statistics results for BMI, 38 SCZ, 11 BIP, 39 and MD. 40 The BMI data were obtained from GIANT and UK BioBank (n = 795 640). The MD data were generated by meta-analyzing the Psychiatric Genomics Consortium GWAS and the …

WebFeb 25, 2024 · Clinical characteristics of the 42,393 individuals included in the GWAS are shown in Table 1, and further details categorized by disease status are in Additional file 1: Tables S1–S3. The leading SNPs in association with CAD, IS, and CCD for each group are described in Table 2.The full lists of genome-wide significant (P-value < 5 × 10 –8) and … fur in or outWebof FTO (fat mass and obesity associated gene) with obesity-related traits: a GWAS for anthropometric traits,9 a GWAS for early-onset severe obesity,10 a GWAS for type 2 … github repositories for beginnersWebAug 12, 2024 · 4.2 Summary Statistics for Smoking Stratified Models. 4.3 Summary Statistics for Gene x Physical Activity. 5 2016 GIANT Body Shape Meta-analysis. 6 GIANT Consortium 2012-2015 GWAS Summary Statistics. 6.1 GWAS Age-/Sex-Stratified 2015 BMI and WHR Summary Statistics. 6.2 GWAS Anthropometric 2015 BMI Summary Statistics. furinno twin laval button tufted bed frame github repository google searchWebJul 2, 2024 · In the genome era, genome-wide association study (GWAS) is a major and effective approach to discover genes and SNPs that contribute to complex diseases. To date, 46 obesity GWASs and 12 meta-analyses had reported 445 SNPs involved in 389 genes with a significant threshold P < 5×10 −8. The future challenge of obesity genetic … fur in poopWebJan 24, 2024 · The obesity- and eBMD-associated TBX15 gene has highly tissue-specific expression unlike its neighbour, WARS2. TBX15 is highly and preferentially expressed in tissues or cell types relevant to the studied GWAS traits. It is associated with WHR adjBMI, WC adjBMI and BMI in many GWAS (Supplementary Table 1). Of all the obesity-trait … fur in rainforestWebBackground Lung function is a heritable complex phenotype with obesity being one of its important risk factors. However, knowledge of their shared genetic basis is limited. Most genome-wide association studies (GWASs) for lung function have been based on European populations, limiting the generalisability across populations. Large-scale lung function … fur in plastic