Webprotein 1 (CLPTM1L) (9-11). These genes have multiple cancer risk loci and may be associated with tumorigenesis. TERT is the catalytic subunit of telomerase, and is … WebJul 14, 2024 · The mechanism of the lumenal translocation of GlcN-PI is unclear. We report that Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), an ER membrane protein of unknown function, is a lipid scramblase involved in GPI biosynthesis. Purified CLPTM1L scrambles GlcN-PI, PI, and several other phospholipids in vitro.

CLPTM1L Is Overexpressed in Lung Cancer and …

Web10). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10 -9), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10 -9).Our results identify a genetic locus associated … WebDec 16, 2016 · Several genome-wide association studies (GWAS) have identified TERT-CLPTM1L as plausible causative locus for lung cancer … cold room manufacturers in chennai

Targeted biologic inhibition of both tumor cell-intrinsic and

WebJul 7, 2010 · Abstract. Background: A recent study reported genetic variants in the TERT-CLPTM1L locus that were associated with mean telomere length, and with risk of multiple cancers.Methods: We evaluated the association between single nucleotide polymorphism (SNP) rs401681 (C > T) and mean telomere length, using quantitative real-time PCR, in … WebJan 17, 2015 · The rs401681 polymorphism was located in the intron 13 of CLPTM1L and 27 kb from the TERT, which has been widely reported to be associated with an … OVCAR4, HeyA8, PeO1, PeO4 Panc1, MiaPaCa2, CaPan2, A549, H226, and H520 human tumor cells were obtained from ATCC. A2780 parental and cisplatin resistant A2780cis cells were obtained from Millipore Sigma (St. Louis, MO). OVCAR5 cell line was purchased from NCI-DCTD repository and authenticated … See more A full FDA panel of normal human tissues on tissue microarray (TMA) (H1.0 × 144) was obtained from Proteogenex (Inglewood, CA). A … See more Cells were plated on 24-well tissue culture plates at equal density (~80) confluence and allowed to attach overnight before treatment as indicated in at least triplicate. Culture media contained yoyo-1 fluorescent DNA … See more Protein expression was accessed by western blotting as discussed earlier35. Briefly cells were lysed with 100 μL of 1× NP40 lysis buffer containing proteinase inhibitors, sheared … See more Cells were plated at equal density on 24-well tissue culture plates and treated as indicated. Cells were treated with monoclonal anti-CLPTM1L for 24 h followed by 72 h of … See more d r mechanical nj