Chmfl-flt3-362
WebCHMFL-FLT3-122 is a potent and selective FLT3 inhibitor (IC 50 = 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro. Induces apoptosis by arresting cell cycle in G 0 /G 1 phase in vitro. Suppresses tumor growth in an AML xenograft model. Modestly orally bioavailable. http://www.china.org.cn/china/2024-06/13/content_76158506.htm
Chmfl-flt3-362
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http://english.hf.cas.cn/new/news/rn/202405/t20240519_237235.html WebMar 18, 2014 · Discovery of a Potent and Selective FLT3 Inhibitor (Z)-N- (5- ( (5-Fluoro-2-oxoindolin-3-ylidene)methyl)-4-methyl-1H-pyrrol-3-yl)-3- (pyrrolidin-1-yl)propanamide with Improved Drug-like Properties and Superior Efficacy in …
http://www.xinhuanet.com/english/2024-06/12/c_139134616.htm WebMay 19, 2024 · Chinese researchers have developed a new drug that can inhibit blood cancer growth with less harm to healthy cells than current therapies. The drug CHMFL …
WebApr 2, 2024 · A series of pyrrolo[2,3-d]pyrimidine derivatives were prepared and optimized for cytotoxic activities against FLT3-ITD mutant cancer cells. Among them, compound 9u possessed nanomolar FLT3 inhibitory activities and subnanomolar inhibitory activities against MV4-11 and Molm-13 cells. It also showed excellent inhibitory activities in FLT3 … WebDec 2, 2015 · On the basis of the structure of PCI-32765 (ibrutinib), a BTK kinase inhibitor that was recently reported to bear FLT3 kinase activity through a structure-guided drug …
WebSep 24, 2024 · Recently, a research team led by Dr. LIU Qingsong and Dr. LIU Jing from High Magnetic Field Laboratory of the Chinese Academy of Sciences has discovered a …
WebApr 2, 2024 · Discovery of N- (4- (6-Acetamidopyrimidin-4-yloxy)phenyl)-2- (2- (trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia. Xiaofei Liang, Bei-lei Wang, +18 authors Q. Liu Biology, Chemistry … hunt whip lashWebFeb 28, 2024 · Fig. 3: CHMFL-26 can effectively inhibit the phosphorylation of HER2 and its downstream signaling pathway, arrest cell cycle progression, induce cell apoptosis and inhibit cell colony formation... mary chitwood mdWebFeb 28, 2024 · Fig. 3: CHMFL-26 can effectively inhibit the phosphorylation of HER2 and its downstream signaling pathway, arrest cell cycle progression, induce cell apoptosis and … mary chirwa biographyWebCatalog No. LS22754 Molecular Formula: C26H29N7O2 Bulk Inquiry Technical Information Aviliable Sizes CHMFL-FLT3-122 is a potent and selective FLT3 inhibitor with IC50 of 40 … hunt whitehead attorneyWebCHMFL-FLT3-122 is a potent and selective FLT3 inhibitor (IC 50 = 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro. … mary chmelik arnpWebJun 13, 2024 · The drug CHMFL-FLT3-362 is designed to treat patients with a form of acute myeloid leukemia (AML) in which the kinase FLT3 is mutated, researchers at the Hefei … hunt whiteheadWebOct 17, 2024 · A class of 1,4-diaryl-1,2,3-triazolo-based ureas synthesized and developed as novel FLT3 inhibitors demonstrated promising oral in vivo efficacy in a MV4-11 cell xenografted mouse model and might be a potent lead compound for further development to treatFLT3-ITD driven acute myloid leukemia. 4 PDF mary chirwa trending video