WebDec 1, 1979 · We studied the pharmacokinetics of chloramphenicol following its intravenous administration as the sodium succinate ester to 54 infants and children. The mean “apparent t1//2” of chloramphenicol clearance from the plasma was 5.94 hours (range 0.87 to 17.8 hours). The t1/2 of patients who weighed less than 10 kg was … WebTotal urinary excretion of chloramphenicol in these studies ranged from a low of 68% to a high of 99% over a three-day period. From 8% to 12% of the antibiotic excreted is in the form of free chloramphenicol; the remainder consists of microbiologically inactive metabolites, principally the conjugate with glucuronic acid.

Chloramphenicol - Wikipedia

Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only recommended when … See more The original indication of chloramphenicol was in the treatment of typhoid, but the presence of multiple drug-resistant Salmonella Typhi has meant it is seldom used for this indication except when the organism is known … See more Chloramphenicol is extremely lipid-soluble; it remains relatively unbound to protein and is a small molecule. It has a large apparent See more Chloramphenicol was first isolated from Streptomyces venezuelae in 1947 and in 1949 a team of scientists at Parke-Davis including Mildred Rebstock published their identification of the chemical structure and their synthesis. In 1972, Senator See more Although its use in veterinary medicine is highly restricted, chloramphenicol still has some important veterinary uses. It is currently considered the most useful treatment of chlamydial disease in koalas. The pharmacokinetics of chloramphenicol have been … See more Aplastic anemia The most serious side effect of chloramphenicol treatment is aplastic anaemia. … See more Chloramphenicol is a bacteriostatic agent, inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity … See more Names Chloramphenicol is available as a generic worldwide under many brandnames and also under various generic names in eastern Europe and … See more Web6.1 Absorption, distribution, metabolism, and excretion ..... 29 6.2 Toxicity ... Chloramphenicol was isolated from Streptomyces venezuelae in 1947. Chloramphenicol was found to be effective against typhus in 1948 and became the first antibiotic to dragonslayer shield

Chloramphenicol use while Breastfeeding Drugs.com

WebTwo mechanisms are of primary importance in the elimination of chloramphenicol from the body — namely, inactivation through conjugation with glucuronic acid, 22 and renal excretion of free ... http://editor.fresenius-kabi.us/PIs/Chloramphenicol_for_Inj_45841E_Jan_08.pdf WebInactivation occurs primarily by hepatic glucuronidation. Hepatic insufficiency is known to decrease metabolism but rarely requires dose modification. Chloramphenicol has an … dragon slayer shortbow